Thrombin generation in a representative plasma with an inhibitor to factor XI in the absence and in the presence of increasing concentrations of recombinant factor VIIa. Thrombin generation was induced by recalcification in the presence of phospholipids. Numbers next to the plots denote final concentrations (μg/mL) of recombinant factor VIIa. The completely flat plot in the absence of recombinant factor VIIa is identical to the plots of thrombin generation in the plasma of homozygotes for type II mutation without an inhibitor (not shown).