LF 15-0195 sensitizes Jurkat T cells to AICD.

(A) Chemical structure of LF 15-0195 and related compounds. (B) Influence of the 3 tested compounds on survival of animals in the graft-versus-host model. (C) Influence of the 3 indicated compounds' pretreatment (0.1 μM for 3 days) on anti-CD95–induced Jurkat cell death (CH11, 25 ng/mL for indicated times). Apoptosis was studied by Hoechst 33342 staining of the nuclear chromatin.