Fig. 7.
LF 15-0195 sensitizes donor T cells to AICD in BMT model.
Irradiated BALB/c mice were engrafted with bone marrow and 3 × 106 splenic T cells from either B6 (A-B) or lprB6 (C-D), then left untreated (A,C) or treated with daily subcutaneous injection of LF 15-0195 from day 3 to day 6 (B,D). Animals were humanely killed at day 6, and apoptosis was measured in by annexin-V staining of CD3+ cells among donor (H2b-gated) splenocytes. Numbers indicate the percentages of apoptotic cells in representative animals from each group.
