Inhibition of VEGF results in reduced thymic atrophy in tumor-bearing animals. Inhibition of VEGF signaling in tumor-bearing animals by Flt-1(1-3)IgG is able to significantly reverse tumor-associated thymic atrophy. (A) Thymus weight (mg) ± Flt-1(1-3)IgG. Heavy horizontal bars represent mean thymus weight per group of mice. (B) Average tumor burden ± Flt-1(1-3)IgG. Flt-1(1-3)IgG low dose: 10 mg/kg twice weekly; high dose: 15 mg/kg every other day. *Denotes statistical significance. Error bars indicate SE.