ZAP-70 outliers show a distinct CD38 expression pattern.ZAP-70 mRNA expression and CD38 status is shown for (A) 78 patients with Ig-mutated CLL and (B) 29 patients with Ig-unmutated CLL. Open symbols represent CLL samples concordant for mutational status and ZAP-70 expression, and filled symbols represent ZAP-70 outliers. The dashed lines indicate the cutoff between Ig-mutated and Ig-unmutated CLL.