Dendrogam representing the hierarchic clustering of MM patients in stage III and PCL with known bone lesions; score based on the genes of Igλ expression signature. (A) Hierarchic tree of 53 MMs (preliminary group). (B) Hierarchic tree of 19 MMs (validation group). Blue-colored branches represent MMs showing absence or limited bone lesions; black branches represent MMs displaying multiple bone lesions. (C) RT-PCR experiments showing Mip-1α mRNA expression in 8 patients, labeled (+) for multiple bone lesions or (–) for absence of or limited bone lesions. Control indicates no template in the PCR reaction.