mAb AA98 inhibits angiogenesis in CAM assays. (A-B) CAM angiogenesis assays showing an almost avascular area in the CAM where the disk carrying 10 μg mAb AA98 was implanted and incubated for 24 hours (A). Normal vascularized CAMs were observed with 10 μg mIgG for 24 hours (B). White arrowheads point to implanted disk, and black arrowheads indicate the borders of the almost avascular area. (C) The number of small branching capillaries was counted within a defined area of 72 mm²surrounding the implanted disk. In each group, 10 embryos were used and the data represent the mean values (± SEM).