American Society of Hematology

Figure 3.

$Figure 3. CD8+ lymphocytes from patients with acute MS display increased rolling and sticking in brain venules. CD8+ cells were isolated from 4 patients and 4 healthy controls. Experiments were performed in 4 mice. Seven venules were examined. (A) Rolling and arrest fractions were compared between healthy controls (□) and patients with acute MS (▪). Mean ± SD are presented. *P < .04. (B) Velocity histograms were generated as described in the legend to Figure 1B. Fifty-nine rolling cells were examined from healthy donors (□), and 64 rolling cells were considered from patients with acute MS (▪). (C) Adherent CD8+ T cells obtained from a healthy donor (Healthy) (CMFDA-labeled) and a patient with acute MS (MS) (CMTMR-labeled) in the same cerebral venule. Note the difference in the number of adherent cells between the 2 populations.$

CD8⁺lymphocytes from patients with acute MS display increasedrolling and sticking in brain venules. CD8⁺ cells were isolated from 4 patients and 4 healthy controls. Experiments were performed in 4 mice. Seven venules were examined. (A) Rolling and arrest fractions were compared between healthy controls (□) and patients with acute MS (▪). Mean ± SD are presented. *P < .04. (B) Velocity histograms were generated as described in the legend to Figure 1B. Fifty-nine rolling cells were examined from healthy donors (□), and 64 rolling cells were considered from patients with acute MS (▪). (C) Adherent CD8⁺ T cells obtained from a healthy donor (Healthy) (CMFDA-labeled) and a patient with acute MS (MS) (CMTMR-labeled) in the same cerebral venule. Note the difference in the number of adherent cells between the 2 populations.

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