Influence of rhIL-11 on clearance of infused VWF and FVIII in homozygous VWD dogs. Two homozygous VWD dogs, C94 and B80, were infused twice with canine cryoprecipitate either in their naive state (open symbols, average values labeled), or following 7 days of pretreatment with rhIL-11 (filled symbols, average values labeled) and with continuing daily rhIL-11 treatments through infusion and sampling (ie, a total of 14 days of rhIL-11 therapy). (A) The change in VWF:Ag levels expressed as a percentage of normal canine VWF:Ag levels. (Note: both dogs had pretreatment values below 1%.) (B) The increase in FVIII activity with rhIL-11 treatment in the same experiments as in panel A.