PGRP-S^-/- mice have higher bacterial load following intraperitoneal infection withB subtilis and M luteus but not S aureus and E coli.PGRP-S^+/+ (light gray bars) or PGRP-S^-/- (dark gray bars) mice were injected intraperitoneally with 2 × 10⁹B subtilis (n = 9/group), 15 × 10⁹M luteus,4 × 10⁸S aureus, or 1.5 × 10⁸E coli (n = 8/group), and bacterial loads in tissue fluids and organs at 24 to 36 hours after challenge were determined. The significance of differences was calculated using the Mann-Whitney U test.