Figure 6.
![Figure 6. In vivo uptake and retention of radioiodide in myeloma tumor xenografts. ARH-77 and ARH-77-NIS cells were implanted into SCID mice. When the tumors reached a mean diameter of 0.6 cm, the mice were injected with 123I intraperitoneally (500 μCi [18.5 MBq]) and imaged using a gamma camera. The image is taken 4 hours after isotope injection. The mouse on the left (A) has a tumor not expressing hNIS, while the 2 mice on the right (B-C) have tumors expressing hNIS. Iodide uptake in the tumors can be clearly seen in their left flank. Normal iodide uptake in the thyroid, stomach, and in the bladder due to renal excretion is seen in all.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/102/2/10.1182_blood-2002-11-3390/6/h81434650006.jpeg?Expires=1735502804&Signature=JjcRBGMdqEXEjr7uEiyoS6stIvZAJYR5HQQ6QqiQHov66ASPyYUS3VkHQwfRy0rVa3sXt1MiPPHBHzjVQbR3e89k1HDJhpBdR0fKwFO0igVy8F7tpsXamxu9xN21PoP9~EeH~ym4iDreavjFia02p4yeftejNSn144tOT46rBUIyJz8Dybou6Ge45ZWvC0OaivfFxrNo8CB-QzgHVJZXAb30RmI0ah4swn9mqvEWmsLedMRzOsox50dgOAx4z4-wIUHxztf-Y7eTwoxiNjJkxR0sxHG37kEiq9yWZcb~aHoG8jjDHdFXwIwBK6DhEsBmbNTPe3K-2tvpElIhmwfamw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
In vivo uptake and retention of radioiodide in myeloma tumor xenografts. ARH-77 and ARH-77-NIS cells were implanted into SCID mice. When the tumors reached a mean diameter of 0.6 cm, the mice were injected with 123I intraperitoneally (500 μCi [18.5 MBq]) and imaged using a gamma camera. The image is taken 4 hours after isotope injection. The mouse on the left (A) has a tumor not expressing hNIS, while the 2 mice on the right (B-C) have tumors expressing hNIS. Iodide uptake in the tumors can be clearly seen in their left flank. Normal iodide uptake in the thyroid, stomach, and in the bladder due to renal excretion is seen in all.
