MLL-ENL—associated genes in T-ALL. The 100 genes most closely associated with MLL-ENL expression—either up-regulated (red) or down-regulated (blue)—are shown, based on a nearest-neighbor analysis. Each column represents a sample and each row, a gene. Numbers at the bottom indicate sample order (sample order is preserved in Figures 4, 5, and 6, and in Table S1 of the supplemental material). Normalized expression values are represented by colors (red, levels greater than the mean; blue, levels lower than the mean). The bar at the bottom shows the correlation between shifts in color and differences in gene expression, from - 3 to + 3 standard deviations. The full list of the top 100 genes positively and negatively associated with the MLL T-ALL category is included as Table S3 in the supplemental material.