Summary of various mouse models and their resemblance to human psoriasis. The top line indicates whether characteristic changes are seen in human psoriasis (Y for yes, N for no). Other models are compared with the human standard and are blocked in green if they match human psoriasis or in red if they do not match. Question marks and the yellow blocks indicate that the feature in question was not examined. Note that only 2 models precisely match human psoriasis in all the features indicated here—a xenotransplantation model in which human psoriatic skin was transplanted onto a SCID mouse (second line) and the K14VEGF transgenic mouse discussed (third line).