K14-VEGF mice exhibit epidermal microabscesses and inflammatory infiltrates characteristic of human psoriasis. (A) Munro-like microabscess. (B) Kogoj-like microabscesses. Progressive increase of mast cell (C-E) and macrophage (F-H) density with 3-month-old (D, G) and 6-month-old (E, H) transgenic mice compared with wild-type littermates (C, F). CD4⁺ T-lymphocytes were detected primarily in the dermis (I) and CD8⁺ T-lymphocytes in the epidermis of 6-month-old transgenic mice (J). E indicates epidermis; D, dermis.