VEGF Trap normalizes the psoriatic phenotype in K14VEGF transgenic mice. Transgenic mice with severe skin lesions were injected with VEGF Trap (25 mg/kg) on days 0, 3, 7, and 12. Tissue was harvested on day 14 for histologic analysis. H&E staining of mouse ear skin treated with VEGF Trap showed clear resolution of rete ridges (compare panels A and B) and decreased parakeratosis/hyperkeratosis (compare panels C and D). Immunostaining with PECAM showed a drop-off of microvessels in the papillary dermis (compare panels E and F). Immunostaining with keratin K6 and E-selectin each showed remarkable down-regulation of signals in the epidermis (compare panels G and H), dermal capillaries (compare panels I and J), respectively. Arrowheads in panel I denote positive staining of blood vessels for E selectin. CD8⁺ T-lymphocytes shifted localization from the epidermis to the dermis in treated animals (compare panels K and L). E indicates epidermis; D, dermis.