Figure 1.
Figure 1. [II–/– → wt] chimeric mice develop systemic and lethal autoimmune disease. Wt or II–/– mice were lethally irradiated and received transplants from either wt or II–/– B6 donors. (A) Clinical GVHD scores35 and (B) survivals after BMT were monitored. [wt → wt], n = 38; [wt → II–/–], n = 29; and [II–/– → wt], n = 35. Results from 3 similar experiments are combined and mean ± SE of clinical scores is shown. *P < .001, ** P < .005.

[II/ → wt] chimeric mice develop systemic and lethal autoimmune disease. Wt or II/– mice were lethally irradiated and received transplants from either wt or II–/– B6 donors. (A) Clinical GVHD scores35  and (B) survivals after BMT were monitored. [wt → wt], n = 38; [wt → II/–], n = 29; and [II/– → wt], n = 35. Results from 3 similar experiments are combined and mean ± SE of clinical scores is shown. *P < .001, ** P < .005.

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