Monocyte recruitment in LFA-1^-/- mice. (A) Time course of TG-induced cell recruitment in LFA-1^+/+ (•) and LFA-1^-/- (▴) mice. (B) The effect on LFA-1^-/- monocyte recruitment by purified Fab fragments in vivo. Significant inhibition of monocyte recruitment at 4 hours occurred with mAb PS2/3 (α4) but not with mAb 5C6 (Mac-1, CD11b) when compared with the PBS control. (C) Early monocyte () and neutrophil (□) recruitment in LFA-1^-/- mice. Significant recruitment was determined by comparing with the 0-hour control. Data shown are representative of 3 or more experiments (**P ≤ .01; *P ≤ .05; means of 4-6 mice per group, ± SEM).