Purging of Burkitt lymphoma, follicular lymphoma, and multiple myeloma cells. (A) Representative histograms of viable Burkitt lymphoma cells analyzed by flow cytometry following reovirus purging. Apheresis product cells were mixed with Burkitt lymphoma cells (1%) and purged for 3 days with reovirus. Samples were analyzed by flow cytometry using Dim CD10⁺CD19⁺ B cells. The λ-positive Burkitt lymphoma cells were detected in both purged and unpurged samples. (B) Representative histograms of viable follicular lymphoma cells analyzed by flow cytometry following reovirus purging. Apheresis product cells were mixed with follicular lymphoma cells (1%) and purged for 3 days with reovirus. Samples were analyzed by flow cytometry using Dim CD10⁺CD19⁺CD20⁺ B cells. The λ-positive follicular lymphoma cells were detected in both purged and unpurged samples. (C) Representative histograms of viable multiple myeloma cells analyzed by flow cytometry following reovirus purging. Apheresis product cells were mixed with multiple myeloma cells (5%) and purged for 5 days with reovirus. Samples were analyzed by flow cytometry using CD138⁺CD38⁺ dimCD45⁺ cells. More than 50% of myeloma cells were purged by reovirus.