Schematic representation of the chimeric human/mouse GPIXs. Chimeric human/mouse GPIX constructs were generated to dissect the human GPIX into 3 domains and assess the contribution of each domain to quinine-dependent antibody binding. Figure depicts the leucine-rich motif (LRM) and the regions which precede (N) and proceed (C-ext) it. The portions shown in black are of mouse origin, whereas the white boxes denote human origin. Single-letter amino acid codes are used.