The homing of NK and NK T cells to the BM, but not the spleen, of NOD/SCID mice is dependent on Gαi signaling and CXCR4. (A) The homing (4 hours) and accumulation (24 hours) of NK and NK T cells to the BM were reduced when cells were treated with either PTX or anti-CXCR4 neutralizing antibody. (B) The homing (4 hours) of NK and NK T cells to the spleen is not dependent on Gαi signaling and CXCR4. The accumulation (24 hours) of NK and NK T cells to the spleen was reduced when cells were treated with either PTX or anti-CXCR4 neutralizing antibody. The results represent the average of 3 independent experiments ± SE. *P < .05.