Figure 6.
Figure 6. PT-100 hematopoietic activity does not require CD26. (A-B) Changes in ANCs in B6, BALB/c CD26+/+ (A) and B6, BALB/c CD26–/– (B) mice treated with CYP (250 mg/kg) on day 0 and administered 10 μg PT-100 (•) or saline (○) orally and 3 times daily from day 3 to day 6. Data are expressed as mean ± SD from 3 to 5 mice per group. Mean ANC in normal mice are indicated by horizontal bars. (C) ANCs in normal B6, BALB/c CD26+/+ (▪), and B6, BALB/c CD26–/– (□) mice after the oral administration of 25 μg PT-100 3 times daily for 5 days. (D) Changes in IL-6 levels in supernatants of Fischer D+ (•) and D– (○) rat BM stromal cells cultured for 24 hours in varying concentrations of PT-100, as indicated on abscissa. Rat IL-6 levels were determined using ELISA. Data are expressed as mean ± SD from triplicate cultures and are representative of 3 separate experiments.

PT-100 hematopoietic activity does not require CD26. (A-B) Changes in ANCs in B6, BALB/c CD26+/+ (A) and B6, BALB/c CD26–/– (B) mice treated with CYP (250 mg/kg) on day 0 and administered 10 μg PT-100 (•) or saline (○) orally and 3 times daily from day 3 to day 6. Data are expressed as mean ± SD from 3 to 5 mice per group. Mean ANC in normal mice are indicated by horizontal bars. (C) ANCs in normal B6, BALB/c CD26+/+ (▪), and B6, BALB/c CD26–/– (□) mice after the oral administration of 25 μg PT-100 3 times daily for 5 days. (D) Changes in IL-6 levels in supernatants of Fischer D+ (•) and D– (○) rat BM stromal cells cultured for 24 hours in varying concentrations of PT-100, as indicated on abscissa. Rat IL-6 levels were determined using ELISA. Data are expressed as mean ± SD from triplicate cultures and are representative of 3 separate experiments.

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