Figure 4.
Surface expression of NCRS in polyclonal NK cell lines from LDGL patients. The same NKLGL lines illustrated in Figure 1 were stained with different anti-NCR mAbs. These were represented by BAB281 mAb specific for NKp46, by Z25 mAb specific for NKp30, and by Z231 mAb specific for NKp44. Isotype controls are represented by open profiles; gray profiles represent the reactivity with the above mAbs. The 2 controls (CTR1 and CTR2) differ for the expression of NCRs because CTR1 was brightly stained by all the mAbs, whereas CTR2 displayed a bimodal distribution (ie, bright versus dull) of both NKp46 and NKp30 molecules.