Pharmacokinetics of recombinant human activated protein C (rhAPC) in the human endotoxin (LPS) model. Healthy male volunteers received rhAPC (24 μg/kg per hour for 8 hours; ▪), which increased APC levels 70-fold (top graph), or placebo (○) intravenously starting 2 hours before LPS bolus infusion (2 ng/kg), which enhanced endogenous protein C activation (2.3-fold; 95% CI, 1.4-3.1). Friedman ANOVA for PC:Ag and PC:Act in both groups: P < .001; P = ns between groups; mean ± SEM.