Activation and subsequent inhibition of fibrinolysis by endotoxin. Healthy male volunteers received rhAPC (24 μg/kg per hour for 8 hours; ▪) or placebo (○) intravenously starting 2 hours before LPS challenge (2 ng/kg). Plasmin antiplasmin complexes (PAP; top graph), tissue plasminogen activator (tPA; middle graph), or plasminogen activator inhibitor (PAI-1; bottom graph). P < .001 versus baseline for both groups, and P = ns between groups; mean ± SEM.