Effects of recombinant human activated protein C (rhAPC) on endotoxin (LPS)–induced changes in vital parameters. Healthy male volunteers received rhAPC (24 μg/kg per hour for 8 hours, ▪) or placebo (○) intravenously starting 2 hours before LPS challenge (2 ng/kg). rhAPC did not significantly alter vital parameters: heart rate (HR; top graph), systolic blood pressure (SBP; middle graph), and diastolic blood pressure (DBP; bottom graph). P < .001 for Friedman ANOVA for both groups, and P = ns between groups; mean ± SEM.