KS tumor lysate stimulates KSHV-specific CD8 T cells. KSHV–tetramer-positive, CD8⁺ CTLs increased in number during each day of an SLR (in an HLA-A*201–positive patient, patient 2). In this experiment, monocyte-derived DCs were pulsed with tumor lysate before pulsing of autologous T cells. The double-positive population increased from 0.02% on day 1 to 38% on day 5.