Distribution of the BCL-6 somatic mutations in both alleles of t(3;14) lymphoma. (A) Frequency of mutations in the BCL-6 major mutation cluster region observed within the translocated (T) and the untranslocated (UT) allele. (B) Mutations in BCL-6 first intron relative to junction sites in 6 lymphomas with t(3;14) translocation. The figure is a composite and shows mutations in BCL-6 in der(14q32) (shaded bars) and in der(3q27) (open bars). Mutational frequency in the BCL-6 locus permitted a direct comparison of rates for all derivative chromosomes.