Potential topoII sites in FLT3 exons 14 and 20. Top: consensus topoII recognition sequence. Bottom: the entire exons 14 and 20 were searched, but only sequences flanking potential sites are shown. Percentages under potential sites refer to homology on the sense/antisense DNA strands, respectively. Homologous nucleotides are underlined and tyrosine residues identified as vertical arrows. The EcoRV site that covers D835 and I836 in exon 20 is underlined.