Synergistic effect of KRX-725 and bFGF in the corneal pocket assay. (A) Hydron pellets containing bFGF (80 ng), KRX-725 (10 μg), or myristoylated control peptide (10 μg) were implanted into micropockets within the corneas of C57BL/6 mice. Blood vessel formation was assessed by stereoscopy. Angiogenic response after 8 days is presented (representative pictures from 4 repeats in each experimental group). Arrows indicate weakly visible vessels. (B) Quantitation of the response at days 4 and 8 after implantation, using the formula (vessel length) × (clock hour of vessel sprouting from limbus) × 2 π/(pellet distance from limbus).