Figure 1.
Dose-dependent effect of imatinib mesylate on autonomous BFU-E formation. PB mononuclear cells (MNCs) (1 × 105/mL) from 4 patients with PV were cultured in semisolid medium together with graded amounts of imatinib mesylate (0.01 to 10 μM) in the absence of exogenous growth factors. Autonomous BFU-E formation was assessed after a culture period of 14 days. The mean BFU-E numbers of triplicates (+ standard deviation) are given from 1 representative experiment (patient M).
