Figure 6.
Figure 6. Percentages of apoptotic cells. U937 cells ectopically expressing Bcl-2, Bcl-xL, or dominant-negative caspase-8 (C8-DN), as well as their respective empty vector controls (pCEP4 for Bcl-2; pcDNA 3.1 for Bcl-xL, C8-DN) were exposed to 400 nM 17-AAG and 75 nM UCN-01 for 30 hours, after which the percentage of apoptotic cells was determined as described in “Materials and methods.” *Significantly less than values for empty vector controls; P > .05; **P < .005. Values represent the means ± SDs for 3 separate experiments performed in triplicate.

Percentages of apoptotic cells. U937 cells ectopically expressing Bcl-2, Bcl-xL, or dominant-negative caspase-8 (C8-DN), as well as their respective empty vector controls (pCEP4 for Bcl-2; pcDNA 3.1 for Bcl-xL, C8-DN) were exposed to 400 nM 17-AAG and 75 nM UCN-01 for 30 hours, after which the percentage of apoptotic cells was determined as described in “Materials and methods.” *Significantly less than values for empty vector controls; P > .05; **P < .005. Values represent the means ± SDs for 3 separate experiments performed in triplicate.

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