Figure 7.
Figure 7. 3-Cl-AHPC-mediated Bcl-XL cleavage. Leukemic cells obtained from patient 11 were incubated in the presence and absence of 1 μM 3-Cl-AHPC for varying periods of time (A) or in the presence of 1 μM 3-Cl-AHPC and in the presence and absence of the caspase inhibitor Z-VAD-fluormethylketone (Z-VAD-fmk) (50 μM) for 24 hours (B). Western blots were performed with the use of anti-Bcl-XL antibody as described in “Materials and methods.” Actin levels were used to assess loading.

3-Cl-AHPC-mediated Bcl-XL cleavage. Leukemic cells obtained from patient 11 were incubated in the presence and absence of 1 μM 3-Cl-AHPC for varying periods of time (A) or in the presence of 1 μM 3-Cl-AHPC and in the presence and absence of the caspase inhibitor Z-VAD-fluormethylketone (Z-VAD-fmk) (50 μM) for 24 hours (B). Western blots were performed with the use of anti-Bcl-XL antibody as described in “Materials and methods.” Actin levels were used to assess loading.

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