Summary of the GATA-1 expression profile during erythroid differentiation. The thickness of the bar indicates the level of gene expression. GATA-1 expression starts at the bipotential (erythrocyte and megakaryocyte) progenitor stage (EMP, erythroid/megakaryocytic precursors) and increases upon differentiation into the proerythroblast. Sca1, c-Kit, and GATA-2 were expressed in hematopoietic stem cells (HSCs) and common myeloid progenitors (CMPs), and their expressions decrease with the progression of differentiation. 30 When the expression level of GATA-1 decreases in Ter119+ erythroblasts, hemoglobin (Hb) accumulates in the cells.31 Pro-EB indicates proerythroblast; Baso-EB, basophilic erythroblast; Poly-EB, polychromatic erythroblast; Ortho-EB, orthochromatic erythroblast; RBC, red blood cell.
