Aneuploidy and IgH translocations. The diagram depicts the relationship between IgH translocations, numerical chromosome abnormalities, and ploidy in the 109 Mayo Clinic patients studied. Each column represents a chromosome trisomy/monosomy as detected by karyotype analysis (chromosomes 1 to 23 and Y from left to right). A trisomy (yellow) is shown if the abnormality was present in the abnormal metaphase irrespective of the number of times present. Likewise, a monosomy (red) is shown if the abnormality was present in the abnormal metaphase irrespective of the number of times present. A black band in the right margin indicates that the patient has an IgH translocation, and a light blue band is indicative of absence of the translocation. The left margin indicates whether the patients belong to the nonhyperdiploid variant MM (gray bar at the left indicates nonhyperdiploid MM) or the hyperdiploid variant MM (green bar at the left indicates hyperdiploid). Note the higher proportion of IgH translocations in the nonhyperdiploid group. Tetra indicates tetraploid.