Kaplan-Meier plots for progression-free survival on an intention-to-treat basis by arm. Solid line represents patients randomized to intensive (CVAMP/HDM) arm, and the dotted line represents patients randomized to standard-dose arm (ABCM). (A) All patients (n = 222). (B) GSTP1 105Ile homozygotes (n = 98). (C) GSTP1 105Ile/105Val heterozygotes (n = 86). (D) GSTP1 105Val homozygotes (n = 38).