Figure 4.
Effect of complement inhibition on oxidative burst.N meningitidis H44/76-induced granulocyte and monocyte oxidative burst was measured in whole human blood after a 10-minute incubation with 2 × 108 meningococci/mL in the presence or absence of complement inhibitory mAbs. Antibody concentrations ranged from 6.25 to 25 μg/mL for anti-C2 and anti-D and from 25 to 100 μg/mL for anti-MBL and the isotype control. Note that combining anti-factor D with anti-MBL or anti-C2 enhanced the inhibitory effect. B indicates baseline (unstimulated sample) incubated for 10 minutes (t = 10). Median values of 4 separate experiments are presented.
