CRU regeneration is impaired in the absence of SHIP. CRU numbers in total BM recovered 16 to 20 weeks after transplantation of 10⁶SHIP^+/+ (white diamonds) or SHIP^-/- (dark squares) BM cells into Pep3b recipients is shown. The cell doses used, number of mice analyzed, and the number of repopulated recipients are indicated in Table 2. The normal range indicates the number of CRU ± 95% CI in untreated wild-type mice. Results are expressed as the mean CRU number ± 95% CI in the BM. ^*P < .0001 between SHIP^+/+ and SHIP^-/- values.