Figure 1.
Figure 1. Phenotypic analysis of mutant KitlSl-20J embryos. (A) Intact embryos harvested at 14.5 dpc from crosses of heterozygous mice. KitlSl-20J/KitlSl-20J embryo (right) appears more pale and runted compared with a wild-type littermate (left). (B) Fetal liver harvested from 14.5-dpc KitlSl-20J/KitlSl-20J embryo (right) appears paler and smaller than fetal liver harvested from a wild-type littermate (left). (C) Germ cell development in 13.5-dpc embryos. Genital ridges harvested at 13.5 dpc from KitlSl-20J/KitlSl-20J embryos were devoid of germ cells as demonstrated by lack of alkaline phosphatase staining when compared with genital ridges harvested from wild-type (+/+) littermates. Phosphatase-positive germ cells in wild-type genital ridges are outlined by an oval. Original magnifications: × 8 (A); × 12 (B, C).

Phenotypic analysis of mutantKitlSl-20Jembryos. (A) Intact embryos harvested at 14.5 dpc from crosses of heterozygous mice. KitlSl-20J/KitlSl-20J embryo (right) appears more pale and runted compared with a wild-type littermate (left). (B) Fetal liver harvested from 14.5-dpc KitlSl-20J/KitlSl-20J embryo (right) appears paler and smaller than fetal liver harvested from a wild-type littermate (left). (C) Germ cell development in 13.5-dpc embryos. Genital ridges harvested at 13.5 dpc from KitlSl-20J/KitlSl-20J embryos were devoid of germ cells as demonstrated by lack of alkaline phosphatase staining when compared with genital ridges harvested from wild-type (+/+) littermates. Phosphatase-positive germ cells in wild-type genital ridges are outlined by an oval. Original magnifications: × 8 (A); × 12 (B, C).

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