Hematoxylin and eosin (H/E) sections, immunohistochemistry, and in situ hybridization of NTENL. Representative examples of grade I (A) and grade III (B) nuclear morphologies. Note the smaller nuclei with condensed chromatin in panel A, and the larger nuclei with open chromatin in panel B. Not shown here, an intermediate morphology is grade II. By immunohistochemistry, an NK-NTENL was diffusely CD94⁺ (C) and focally NKG2A⁺ (D). Another NK-NTENL was CD3m^-, with CD3m⁺ small T cells (E). In situ hybridization with the antisense cDNA probe demonstrated CD94⁺ lymphoma cells with focal necrosis (F); a corresponding area stained by the sense cDNA probe showed rare cells with nonspecific staining (G). All at magnification × 1000, H/E on paraffin sections (A-B), immunoperoxidase stains on frozen sections (C-D), or paraffin sections (E-G).