Figure 10.
MyD-1 signaling in monocytes. Ligation of MyD-1 results in the tyrosine phosphorylation of MyD-1 and recruitment of SHP-2. Complex formation allows SHP-2 to act as an adaptor for p85 and results in the activation of PI 3-kinase. Generation of PIP3 leads to the activation of PtdCho-PLD, production of PtdOH, and consequent activation of sphingosine kinase.
