Correlation of vaccine application with clinical response. Correlation of disease development as assessed by TBI and vaccine application was followed over time. Interruption of vaccination led to disease progression with increased TBI. Repeated response was induced after revaccination (•——•) with new tumor lysate (↑) from progressive lesions. In patient 1, interruption of vaccination led to progression of disease (A, week 13). Introduction of a new vaccine using DCs pulsed with tumor lysate of a progressing lesion (A, week 29) induced a treatment response. A similar observation was made in patient 2, when interruption of the vaccination led to disease progression (B, week 8). A change to new tumor lysate led to a clinical response after week 13 (B).