Change of MVD during therapy with SU5416 in a responding patient. Bone marrow histologies from the 74-year-old patient who was treated with SU5416 for 6 months taken prior to therapy (A) and after 8 weeks (B), showing a clear decrease in MVD under therapy. Endothelial cells were stained with an antibody against thrombomodulin (red). Original magnification, × 500.