Cases requiring treatment. Curves represent ing the proportion of cases requiring treatment within monoclonal CLL versus CLL patients with 2 or more B-cell clones during both the overall follow-up (A) and the first 18 months after diagnosis (B). In panel B, CLL + CLL and CLL + non-CLL cases are separately represented. The proportion of cases requiring treatment during the first 18 months after diagnosis (± the 95% confidence interval) is in parentheses for each patient group.