Gross appearance of LLC footpad tumors in mice with single and combined deficits in plasminogen and fibrinogen. A normal, non-tumor–bearing foot (A) is shown along with examples of LLC^GFP footpad tumors 14 days after inoculation into control (B), Plg^– (C,F), Fib^– (D), and Plg^–/Fib^– (E) mice. Despite the minimal difference in size between the Plg^– tumor-bearing foot (C) and a non-tumor–bearing foot (A), the presence of tumor tissue could be easily appreciated using a fluorescence-equipped stereomicroscope (F). Note that the foot in panel F is the same foot shown in panel C and is photographed at the same magnification.