New class-discriminating genes. (A) Shown is a 2-dimensional hierarchic cluster of ALL cases using the newly identified class discriminators from the U133A and B microarrays. Probe set signal values are normalized to the mean for the dataset and then for each individual case are represented by color, with red representing deviation above the mean and green representing deviation below the mean. Genetic subtypes are indicated across the bottom of the panel. (B) Shown are selected genes highly correlated with individual genetic subtypes of ALL. Probe set signal values are normalized to the mean for the dataset, and values for each individual case are represented by color, with red representing deviation above the mean and green representing deviation below the mean. The leukemia subtype is indicated at the bottom of the figure. GenBank accession numbers and gene symbols or DNA sequence names are listed on the right side of the panel.