Confocal fluorescent microscopic studies for transgenic hB^-FVIII and murine VWF. Isolated platelets from FVIII^null animals (top row) and line no. 38 hB^-FVIII/FVIII^null animals (middle and bottom rows) were immunostained for either mouse VWF (left column) or hFVIII (second column from left). The 2 images were overlapped in the third column, showing that in the line no. 38 platelets there was overlap of VWF and hFVIII distributions. Right column shows light microscopy of the platelets.