Correlation of degree of spectratype abnormality with stage of disease. A significant correlation was found between the number of contracted (A) and monoclonal (B) spectratypes and the clinical stage. (C) Quantification and statistical analysis of the number of contracted profiles in CTCL (▪), psoriasis (▴), and healthy donors (▾). A contracted profile was defined as having 0 to 4 distinct peaks. CDR3 spectratyping was performed from CD3⁺ T cells. Statistically significant perturbations of the TCR repertoire of patients with CTCL were found as compared with patients with psoriasis and healthy control donors. Horizontal bars show mean values. Statistical analysis is indicated. (D) Quantification and statistical analysis of the number of monoclonal profiles in patients with CTCL (▪) and psoriasis (▴) and healthy donors (▾). Markedly increased numbers of monoclonal profiles were found in patients with CTCL as compared with patients with psoriasis and healthy control donors. Horizontal bars show mean values. (E-F) BV families appear to be affected in a nonrandom fashion. The percentage of patients with CTCL with contracted (E) and monoclonal (F) profiles is shown.