Platelet adhesion to laminin, fibronectin, and VWF under static conditions. Resting or CRP-activated washed wild-type (□), α2-null (▦), or β1-null (▪) platelets were allowed to adhere for 60 minutes under static conditions to laminin (A), fibronectin (B), or VWF (C) immobilized in microtiter plates. The experiments were performed in the presence of Mg²⁺/Ca²⁺ (1 mM each). Where indicated, platelets were preincubated with anti-αIIbβ3 (JON/A, 50 μg/mL). Adherent platelets were quantitated fluorimetrically. The data shown are from a single experiment representative of 6 identical experiments, and are expressed as the mean of quadruplicate reading ± SD for the indicated times.