Multiple lineages of GFP⁺ cells in clonally repopulated leukemic mice. Shown are a series of FACS analyses of BM cells from representative sick mice injected with 10³ Sca-1⁺lin^–GFP⁺ BCR-ABL⁺ +/+ cells (top row) and SHIP^–/– cells (bottom row). The presence of GFP⁺ cells in the compartments of Gr-1/Mac-1⁺, B220⁺, and CD4/CD8⁺ cells can be seen in recipients of both genotypes of BCR-ABL–transduced cells.