American Society of Hematology

Figure 4.

$Figure 4. Chemotaxis efficiency of total IgG and IgM plasma cells from E/P-/- tissues. Chemotaxis assays were performed with unfractionated cervical lymph node (LN), spleen (SPL), and bone marrow (BM) cells in response to graded concentrations of CXCL12 (SDF-1). The frequencies of IgG (left) and IgM (right) plasma cells in the input and migrated samples were determined by ELISPOT, and the percentages of plasma cells migrated were calculated. The data are represented as the mean ± SEM of several independent experiments. For IgG, n = 4 to 9, and for IgM, n = 2 to 3. The (*) indicates statistically significant migration of LN, SPL, and BM IgG plasma cells compared with basal migration in each tissue. The (#) indicates statistical difference between response of LN compared with SPL or BM at 300 and 100 ng/mL, respectively.$

Chemotaxis efficiency of total IgG and IgM plasma cells from E/P^-/- tissues. Chemotaxis assays were performed with unfractionated cervical lymph node (LN), spleen (SPL), and bone marrow (BM) cells in response to graded concentrations of CXCL12 (SDF-1). The frequencies of IgG (left) and IgM (right) plasma cells in the input and migrated samples were determined by ELISPOT, and the percentages of plasma cells migrated were calculated. The data are represented as the mean ± SEM of several independent experiments. For IgG, n = 4 to 9, and for IgM, n = 2 to 3. The (^*) indicates statistically significant migration of LN, SPL, and BM IgG plasma cells compared with basal migration in each tissue. The (#) indicates statistical difference between response of LN compared with SPL or BM at 300 and 100 ng/mL, respectively.

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